Structural Bioinformatics
Structural bioinformatics is a subset of bioinformatics concerned with the use of biological structures – proteins, DNA, RNA, ligands etc. and complexes thereof to further our understanding of biological systems. The majority of this work uses structures contained in the Protein Data Bank (PDB) and can be subdivided as shown in the following diagram.
Our work concerns a subset of these actions leading to a variety of resources for use in our own research and for access by the community.
Highlights of our work include the study of signaling and apoptosis, classification of protein fold space through structure alignment, ontology development, homology modeling (including work on voltage gated channel proteins), protein functional annotation, data models, query languages and visualization tools. Further details are available from http://www.sdsc.edu/pb. This effort is led by Philip E. Bourne.
